Prof.Arvind Kumar Morya

Dr.Nupur Goel, Dr.Aprajita Sinha, Dr.priya sisodiya

Abstract

Prospective Randomized Clinical Trial PURPOSE: To compare the therapeutic effect of sodium hyaluronate (SH)–trehalose or SH (0.1%)alone in patients with dry eye disease (DED)METHODS: Patients randomized into two groups: SH-trehalose or SH.OSDI questionnaire was used to assess patient's symptoms&followed up at 4&8 weeks,OSDI score,TBUT, TFH, Schirmer's test&conjunctival staining evaluated RESULTS:384 patients, 192 patients in each arm.Mean age was 37.62 + 14.4 years and 225 were women (56%). Improvement in Schirmer's test was significantly better in the SH-trehalose group at 8 wk (5.26 + 4.3 mm) compared toSH group (3.71 + 3.9).There were no group differences at all-time points in terms of conjunctival staining and OSDI-based grades of DED. CONCLUSION: It was found that treating dry eye with SH-trehalose leads to greater improvement in the Schirmer's values and TBUT after 8 weeks of sustained use in patients with DED, and this was more pronounced in those with severe DED.