Dr.Tapan

Dr.Sanjiv Kumar Gupta

Abstract

Design:Prospective, doubleblinded, randomized interventional study.Subjects & methods:60 eyes randomly allocated to 2groups(direct & oblique i/vit inj technique).IOP measured before &immediately after inj of 0.1ml of bevacizumab & dexa & then at 30min after inj. Occurence &amount of vitreous reflux recorded. BCVA & CMT assessed preinj & 6weeks postinj.Results:IOP increased significantly immediately after inj to 24.30±3.02(direct) &31.50±3.49(oblique).Iop rise differed significantly b/w both groups(mean difference:7.2,P <0.0001).30min after inj,no significant difference in IOP increase b/wgroups.Occurence & amount of fluid reflux were significantly higher with direct inj.No significant difference in BCVA & CMT outcome b/w bothgroups.Conclusions:Direct technique has lower rise in IOP & higher incidence of fluid reflux than oblique.Fluid reflux doesn't cause therapeutic compromise in BCVA or CMT changes,so reflux fluid must be vitreous not drug.Thus,direct technique seems to be preferred.