Dr.Sumit Randhir Singh

Dr.Jay Kumar Chhablani

Abstract

Purpose: To report long term changes in pigment epithelial detachment composition indices (PEDCI) in eyes with neovascular age related macular degeneration (n-AMD).
Methods: This was a retrospective case series and included 6 eyes with n-AMD treated with anti-VEGF agents through 84 months. Changes in PEDCI including serous, neovascular and fibrous components (PEDCI-S, N, F respectively), derived using an automated algorithm on a single, registered line scan through fovea, were assessed.
Results: PEDCI-S reduced from 0.60 ± 0.21 (baseline) to 0.17 ± 0.20 (84 months; p = 0.03). PEDCI-N showed significant increase from 0.30 ± 0.15 to 0.71 ± 0.21 whereas PEDCI-F changed minimally from 0.10 ± 0.09 to 0.13 ± 0.11 (p = 0.69) at 84 months.
Conclusion: Serous component in PEDCI shows a reduction with anti-VEGF treatment whereas PEDCI-N increases relative to other constituents at 84 months. PEDCI-F, a marker of scarring, increased minimally and was not predictive of final visual acuity.