Dr.Anasua Ganguly Kapoor

Abstract

Study design: Retrospective case control study Purpose- Study the clinico-morphological characteristics and management outcomes in OSSN with hepatitis B Methodology-Out of 438 OSSN patients 14 patients who had an associated hepatitis B included as cases and 67 as controls
Results- Majority had nodular OSSN with limbus being epicentre similar to control group, however diffuse OSSN, OSSN involving fornix or tarsal conjunctiva were more prominent in cases. 6 (42%) had more than or equal to T3 AJCC grading AJCC grading. Eight underwent wide excision biopsy, one enucleation and 2 exenteration. Base was positive on histopathology in 5 patients, out of which 3 patients received plaque brachytherapy. 2 patients had recurrence. Rest all were tumour free surviving at last follow up.
Conclusion- OSSN occurring in hepatitis B patients is more aggressive with high rate of involvement of forniceal and tarsal conjunctiva with high base positivity, advanced T stage and needs aggressive management.