Dr.Ruju Unadkat

Dr.Rolika Bansal, Dr.Santosh G. Honavar

Abstract

Study design: retrospective interventional Purpose: Correlation between clinical risk factors (CRF) and histopathological risk factors (HRF and life salvage following secondary enucleation for retinoblastoma. Methods: Retrospective interventional study. Results: Of 406 eyes with secondary enucleation, 243 (60%) had CRF at baseline and 122 (30%) had HRF. Of those with baseline CRF, HRF was present in 91 (37%). Of the ones with HRF, baseline CRF were present in 91 (76%). HRF were infiltration of iris 16% ciliary body 21% choroid 46%; optic nerve retrolaminar 15% and resection (7%) scleral lamellar (34%) and extra-scleral (11%). All with HRF received adjuvant chemotherapy. Presence of CRF correlated with HRF, p<0.001. Life salvage was seen in 401 (99%) overall, 132 (100%) with no CRF or HRF and 117 (96%) with HRF at 120+79 months of follow-up. Conclusion: CRF is a predictor of HRF. Discernment of HRF following enucleation and appropriate adjuvant therapy results in excellent life salvage.